A UPS cargo plane crashed shortly after departing Louisville Muhammad Ali International Airport on Tuesday evening. The aircraft, identified as Flight 2976, was en route to Honolulu when the incident occurred, prompting a swift response from local police and emergency services. Authorities reported injuries and issued a shelter-in-place order for areas within five miles of the airport. The Federal Aviation Administration confirmed the crash, and the National Transportation Safety Board will lead the investigation. Eyewitnesses and local media captured images of a large plume of black smoke rising near the airport.