The United States, alongside Israel, launched a large-scale military assault on major cities in Iran, with President Trump framing the operation as an opportunity for regime change. The strikes followed weeks of escalating threats tied to Iran's nuclear program and came after mediated talks failed to produce an agreement. The Department of Defense named the campaign Operation Epic Fury, and officials indicated the assault could continue for several days.

President Trump urged Iranians to overthrow their government after the attacks, saying this could be a rare chance to reshape the country's future. Israeli Prime Minister Benjamin Netanyahu described the joint action as a step toward enabling Iranians to take control of their destiny, reflecting Israel's long-standing position that Iran poses a serious regional and global threat.

Initial targets included government and military sites across Tehran and other cities such as Qom, Kermanshah, Isfahan, and Karaj. Verified footage showed strikes near key leadership compounds, including areas housing the presidential palace and national security institutions. Israeli officials said the first wave aimed to strike senior leaders and multiple military assets.

Iran responded by launching missiles and drones toward Israel and targeting American military bases in Qatar, Kuwait, the United Arab Emirates, and Bahrain. Regional defense officials reported intercepting several attacks, as concerns grow about a broader conflict across the Middle East, where American forces have increased their presence in anticipation of retaliation.