Two large studies conducted by researchers at Ben-Gurion University of the Negev, Clalit Health Services and Soroka Medical Center found no link between common painkiller use during early pregnancy and birth defects or delivery complications. The research analyzed data from more than 250,000 pregnancies, making it among the largest investigations of its kind worldwide.

The findings showed that taking acetaminophen or nonsteroidal anti inflammatory drugs such as ibuprofen, diclofenac and naproxen during the first trimester was not associated with an increased risk of birth defects. The results provide reassurance to pregnant women who may need pain relief and address public concerns raised about the safety of these medications during pregnancy.